Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
نویسندگان
چکیده
منابع مشابه
Molecular determinants of pyrantel selectivity in nicotinic receptors.
Nicotinic receptors (acetylcholine receptors, AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes, and they are targets for antiparasitic drugs. The anthelmintic agents levamisole and pyrantel, which are potent agonists of nematode muscle AChRs, are partial agonists of mammalian muscle AChRs. To further explore the ...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2006
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.106.026336